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The SURMOUNT-MAINTAIN trial will help answer the question of what to do with the obesity medication dose to maintain weight loss long-term
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Semaglutide vs. Tirzepatide for Obesity
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Tirzepatide weight-loss study shows promising results
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SURMOUNT-3: Tirzepatide shows total mean weight loss of 26.6% from study entry over 84 weeks
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Not every patient responds the same to GLP-1 therapy. In the clinical trials, a subset of patients did not achieve ≥5% weight loss—often considered an “inadequate response” in clinical practice. This highlights
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In the SURMOUNT-4 trial, 82.5% of adults with obesity regained ≥25% of initial weight lost within one year of tirzepatide withdrawal; most showed reversal of cardiometabolic improvements. https://ja.ma/4qaMLfO
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Effect of tirzepatide in SURMOUNT-1 trial. (BMI: body mass index; CI:
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