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glp-1 news 2025 october 21 Biased agonism of GLP-1R and GIPR enhances glucose lowering and weight loss, with dual GLP-1R/GIPR biased agonism yielding greater efficacy: Cell Reports Medicine

Marsoni M251S
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Big o
New York, US
★★★★★ 5
Fits good
Color: White, Size: XX-Large
The fit is very good, doesn’t feel irregular. Nice comfy fit and feel.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 6, 2026
A
Verified Purchase
ANDIE
Fort Morgan, US
★★★★★ 5
Finally boy shorts done right
Color: (6 Pack) Brown and Pink, Size: 5X-Large
So am going to be one of those, cause I do wished I had one of these reviews to fall on. First off, I am extremely picky about my panties. I am a large person. So comfort is a necessity. I have to have stretch, but also they have to be tight enough to not move or show things. I like longer legs, stretch, and seamless silky soft material. After YEARS of hunting, I did find some perfect ones from a big brand (Aerie) which are wildly overpriced at $23 per PAIR! Found these and they are perfect. Only difference is these have the thin waistband and the Aerie has the wide yoga waistband. I love these so much I bought 6 packs because I know how hard it’s to find the perfect boy shorts for larger women. Smooth, comfortable, seamless, long, and affordable! I did have to size up 2 sizes. In the other brand a xxxl is perfect.. I got a 5x in these. Probably could have went with the 4x but the 5x gives comfort. Im so glad I did find these.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 27, 2026
A
Verified Purchase
Amazon Customer
West Palm Beach, US
★★★★★ 5
The underwear of all underwear!
Color: (3 Pack) Leopard Print, Size: X-Large
These have quickly become my favorite underwear and even my go-to shorts for lounging around the house. They’re incredibly comfortable and don’t dig in or roll down like so many others I’ve tried. The fit stays in place, and the fabric has a smooth, silky feel that’s really nice against the skin. They’re comfortable enough to wear all day and have held up well so far. I’d definitely recommend them if you’re looking for something soft, comfortable, and easy to wear
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 30, 2026
K
Verified Purchase
Karen Boyd
Lake Worth, US
★★★★★ 5
Most comfortable panty!
Color: (6 Pack) Neutral, Size: XX-Large
When I saw them I was skeptical about the size I should order. At 225 lbs with a blessed backside, a 1X did not seem like the way to go, so I ordered a XXL. That was definitely a good choice. They fit comfortably well with a little breathing room. Love them!
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Reviewed in the United States on May 3, 2026
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Arlene I.
Lowell, US
★★★★★ 3
Just okay, not a fan
Color: (6 Pack) 2-black 2-beige 2-white, Size: Medium
These run a bit large and are very stretchy. They are comfortable with zero tummy/hip support. I’ll wear them in certain circumstances, but would probably not purchase again. I don’t recommend.
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Reviewed in the United States on May 22, 2026

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