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Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
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Peptides are everywhere — biohackers, longevity clinics, gym influencers. But what does the peer-reviewed science actually say? Here's the honest breakdown. Grade A — Strong evidence, FDA approved: Semaglutide (GLP-1) is the
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Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity
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STEP 1 (NEJM 2021) showed that semaglutide 2.4 mg once weekly produced a mean weight loss of 14.9% in 1,961 adults with obesity — with 1 in 3 participants losing over 20%
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New in the May 29, 2025, issue of NEJM: Sotatercept in Pulmonary Arterial Hypertension (ZENITH phase 3 trial) https://nej.md/4iYkLbj Oral Semaglutide and Cardiovascular Outcomes (SOUL trial) https://nej.md/4hHII5M Upadacitinib for Giant-Cell Arteritis
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